Trial Imaging for Stroke
1. What is cerebral stroke?
Cerebral stroke is cerebrovascular disease that causes intracranial hemorrhage or ischemia.
The proportion of ischemic stroke is 70-80 % in cerebral stroke.
Temporal evolution of ischemic strokes are typically categorized into hyperacute (0-6 hours),
acute (6-24 hours), subacute (24 hours to 2 weeks), chronic stroke ( > 2 weeks old).
2. Role of neuroimaging in acute ischemic stroke
Acute ischemic stroke is diagnosed based on clinical symptoms and neuroimaging.
Neuroimaging plays an essential role in the managements of the acute ischemic stroke.
Neuroimaging is used to detect acute ischemic stroke and guide options of treatments.
Representative neuroimaging for the evaluation of acute ischemic stroke are computed tomography (CT)
such as noncontrast brain CT, CT angiography (CTA), CT perfusion (CTP) and magnetic resonance imaging
(MRI) such as diffusion-weighted imaging (DWI), MR angiography (MRA), MR perfusion (MRP) using dynamic
susceptibility contrast (DSC) technique, fluid attenuated inversion recovery (FLAIR), T2* gradient echo imaging
(GRE), and digital subtraction angiography (DSA).
3. Requirements for neuroimaging in clinical trials for acute ischemic stroke
4. Representative outcomes based on neuroimaging in clinical trials for acute ischemic stroke
Infarct core volume
Hemorrhage or hemorrhagic transformation
Revascularization, recanalization, or reperfusion
Does the Apparent Diffusion Coefficient Value Predict Permanent Cerebral Ischemia/Reperfusion
Injury in Rats?
Kwon JI, Woo CW, Kim KW, Choi Y, Kim ST, Kim YJ, Kang J, Lee DW, Tak E, Kim JK, Jung SC, Kim
TH, Woo DC. Acad Radiol. 2019 Jan 17. Full Text
Perfusion CT for prediction of hemorrhagic transformation in acute ischemic stroke: a systematic
review and meta-analysis
Suh CH, Jung SC, Cho SJ, Kim D, Lee JB, Woo DC, Oh WY, Lee JG, Kim KW. Eur Radiol.
2019 Aug;29(8):4077-4087. Full Text
Multicenter Clinical Imaging Management System: Critical Success Factor for Multidisciplinary
Lee K, Sung YS, Suh CH, Woo DC, Oh WY, Lee JG, Jung SC, Kim KW. Journal of the Korean Society of Imaging Informatics in Medicine 2018;24:1-9. Full Text
6. 뇌졸중 임상시험을 위한 영상바이오마커 활용에 대한 강의